Epigenetic therapy in allogeneic hematopoietic stem cell transplantation
نویسندگان
چکیده
منابع مشابه
Epigenetic therapy in allogeneic hematopoietic stem cell transplantation
DNA methylation and other epigenetic phenomena appear to be relevant in the pathogenesis of several malignant disorders. DNA methyltransferases add methyl groups to cytosine-phosphate-guanine (CpG) islandsleading to gene promoter silencing. The DNA methyltransferases inhibitors azacitidine and decitabine have anti-tumor activity against a broad range of malignancies, but have been investigated ...
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ژورنال
عنوان ژورنال: Revista Brasileira de Hematologia e Hemoterapia
سال: 2013
ISSN: 1516-8484
DOI: 10.5581/1516-8484.20130034